Synvisc-One™ (hylan G-F 20) and SYNVISC® (hylan G-F 20) are used to relieve knee pain due to osteoarthritis (OA). They are for patients who do not get enough relief from simple painkillers such as acetaminophen, or from exercise and physical therapy.

Synvisc-One and SYNVISC are generally well tolerated. However, they may not work for everyone. The side effects most commonly seen when Synvisc-One or SYNVISC is injected into the knee were pain, swelling and/or fluid buildup around the knee. Cases where the swelling is extensive or painful should be discussed with your doctor. Other side effects such as rash have been reported rarely. Before trying Synvisc-One or SYNVISC, tell your doctor if you are allergic to products from birds—such as feathers, eggs or poultry—or if your leg is swollen or infected. Talk to your doctor before resuming strenuous weight-bearing activities after treatment. Synvisc-One and SYNVISC have not been tested in children, pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child.